血L-卡尼丁水平与线粒体DNA拷贝数之间的关联
Mingyue Li1, Keming Yang2,3, Immaculata De Vivo4,5,6,7
1Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, 1050 Wishard Boulevard, RG 6124, Indianapolis, IN, 46202-2872, USA.
BMC molecular and cell biology
|December 11, 2023
概括
高血L-卡尼丁水平与男性的线粒体DNA拷贝数 (mtDNAcn) 的降低有关. 这表明卡尼丁代谢,线粒体功能和细胞氧化应激之间存在联系.
科学领域:
- 生物化学 生物化学
- 细胞生物学 细胞生物学
- 分子生物学分子生物学
背景情况:
- 线粒体通过氧化酸化产生细胞能量.
- 线粒体DNA拷贝数 (mtDNAcn) 作为线粒体健康和氧化应激的生物标志物.
- 以前的研究将肥胖和吸烟等生活方式因素与白细胞mtDNAcn.cn减少联系起来.
研究的目的:
- 调查血L-卡尼丁水平与白细胞mtDNAcn之间的关联.
- 探索卡尼丁在线粒体功能和氧化应激中的作用.
主要方法:
- 量化的血L-卡尼丁水平.
- 从健康专业人员随访研究 (HPFS) 中测量了538名美国男性的白细胞mtDNAcn.
- 分析了L-carnitine和mtDNAcn之间的关联,并对潜在的混因素进行了调整.
主要成果:
- 在血L-卡尼丁水平和白细胞mtDNAcn (ρ = -0.1,P = 0.02) 之间观察到一个显著的反向关联.
- 较高的L-卡尼丁度与较低的mtDNAcn.cn相关.
结论:
- 卡尼丁代谢途径可能会影响线粒体功能.
- 血L-卡尼丁水平可能与mtDNAcn.cn.表示的细胞氧化应激水平有关.
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