Y染色体AZFc微删除可能对胚胎欧化有负面影响:一项回顾性队列研究
Wei Jiang1, Qijun Xie1, Xin Li1
1Department of Reproductive Medicine, Nanjing Women and Children's Healthcare Hospital, Women's Hospital of Nanjing Medical University, 123 Tianfei Lane, Mochou Road, Nanjing, Jiangsu, 210004, China.
Y染色体AZFc微切除与更高的胚胎无体积率有关,增加了试管婴儿失败和怀孕流产的风险. 患有这种缺失的夫妇应该考虑进行胚胎选择前植入前遗传检测 (PGT-A).
科学领域:
- 生殖医学 生殖医学
- 人类遗传学 人类遗传学
- 胚胎学 胚胎学
背景情况:
- 胚胎形是导致流产,体外受精 (IVF) 失败和出生缺陷的主要原因.
- Y染色体AZFc微切除与生殖结果有关,但其与胚胎无体积的联系尚未被探索.
研究的目的:
- 为了研究Y染色体AZFc微切除和胚胎无倍化之间的关系.
- 评估AZFc微切除对试管婴儿周期结果的影响.
主要方法:
- 从2016-2022年对513名患者 (603个周期) 的回顾性队列研究.
- 在患有Y染色体AZFc微切除和没有Y染色体AZFc微切除的患者之间比较胚胎积率.
- 使用限制立方线和通用估计方程 (GEE) 的统计分析.
主要成果:
- 患有Y染色体AZFc微切除的患者表现出显著更高的胚胎无倍化率 (33.0%对27.3%).
- 在AZFc微切除组中,正常受精率 (81.5%对90.3%) 和胚胎囊形成率 (47.0%对57.8%) 较低.
- 在群体之间没有观察到经过euploid胚胎移植后怀孕结果的显著差异.
结论:
- Y染色体AZFc微切除与胚胎积症的风险增加有关.
- 患有AZFc微删除的夫妇应被告知增加了形积分发育的易感性.
- 在这些情况下,建议对胚胎进行胚胎选择,进行前植入基因测试 (PGT-A).
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