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阿尔法-防御素在单细胞-巨细胞分化过程中抑制ERK/STAT3信号传递,并阻碍巨细胞功能

Jungnam Lee1, Naweed Mohammad1, Yuanqing Lu1

  • 1Division of Pulmonary, Critical Care and Sleep Medicine, University of Florida, Gainesville, FL, USA.

Respiratory research
|December 11, 2023
PubMed
概括

在α-1-抗素缺乏症 (AATD) 中,高水平的α-defensins通过抑制ERK/STAT3信号传递,损害了巨细胞的功能. 阿尔法-1-抗素 (AAT) 可以恢复巨细胞的迁移和细胞能力,这表明它具有治疗作用.

关键词:
AAT 缺乏症 (AATD) 是一种阿尔法-1-抗素 (AAT) 是一种CD163 是一个CD163 CD163 是一个CD163CD206 是一个CD206 CD206 是一个CD206 CD206在ERK1/2中.在STAT3中,我们可以使用STAT3.这就是α-defensin.

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