相关实验视频

Updated: Jul 8, 2025

Adoptive Transfer of IL-33-Stimulated Macrophages into Bleomycin-Induced Mouse Models to Study Their Effect on Idiopathic Pulmonary Fibrosis In Vivo

Adoptive Transfer of IL-33-Stimulated Macrophages into Bleomycin-Induced Mouse Models to Study Their Effect on Idiopathic Pulmonary Fibrosis In Vivo

Published on: May 5, 2023

IL-33-ST2通路在调节炎症中的作用:目前的证据和未来的前景

Yilu Zhou¹, Zhendong Xu², Zhiqiang Liu³

¹Department of Anesthesiology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.

Journal of translational medicine

|December 12, 2023

概括

介素-33 (IL-33) 和它的受体ST2是肺炎和败血症的关键. 这篇评论探讨了它们在喘,COPD和败血症中的作用,强调了治疗目标.

科学领域:

免疫学和炎症研究研究
分子生物学和信号通路
呼吸系统医学和重症监护

背景情况:

洲际蛋白-33 (IL-33) 是一种在细胞应激时释放的警示蛋白,通过其受体ST2.2激活先天免疫力.
IL-33-ST2轴与2型炎症反应有关,慢性肺部阻塞性疾病 (COPD) 中的水平较高.
由于其对细菌清除,组织修复和高死亡率的影响,IL-33在败血症中的作用引起了人们的注意.

研究的目的:

审查IL-33-ST2轴在肺炎 (喘,慢性肺炎) 和败血症中的功能.
总结目前关于IL-33-ST2途径参与疾病病原发生的研究.
识别和讨论IL-33-ST2信号通路中的潜在治疗点.

主要方法:

对研究IL-33和ST2在喘,COPD和败血症中的研究进行文献综述.
分析IL-33-ST2轴的促炎和免疫调节作用.
综合与向IL-33-ST2通路的治疗策略相关的发现.

主要成果:

IL-33-ST2通路促进2型炎症,并与COPD相关.
IL-33在败血症中起着重要作用,影响细菌清除和组织修复.
在炎症性肺病和败血症中观察到高IL-33和ST2水平.

结论:

IL-33-ST2轴是喘,COPD和败血症的关键调解者.
准IL-33-ST2通路为炎症和传染病提供了潜在的治疗途径.
需要进一步的研究,以充分阐明调节IL-33-ST2信号的治疗潜力.

关键词:

喘喘是一种这里有IL-33和IL-33.炎症炎症是一种炎症.炎症反应是一种炎症反应.败血症这是一种败血症.

更多相关视频

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice

Published on: January 25, 2017

An IL-8 Transiently Transgenized Mouse Model for the In Vivo Long-term Monitoring of Inflammatory Responses

An IL-8 Transiently Transgenized Mouse Model for the In Vivo Long-term Monitoring of Inflammatory Responses

Published on: July 7, 2017

相关概念视频

T Cell Types and Functions

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

The JAK-STAT Signaling Pathway

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...

Inflammatory Response

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...

NF-κB-dependent Signaling Pathway

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...

Inflammatory Bowel Disease IV: Pharmacological Management

Inflammatory Bowel Disease IV: Pharmacological Management

Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...

Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...