在患有关节炎的患者中感染Nocardia pseudobrasiliensis
Youqi Ji1,2, Mengyuan Chen1,3, Xin Hong1,4
1Laboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.
The Journal of international medical research
|December 12, 2023
概括
一个新兴的病原体Nocardia pseudobrasiliensis在一个病人身上引起了水 (关节溢出). 这一案例突出了与Nocardia brasiliensis相比,其独特的侵入性潜力和抗生素敏感性.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 临床案例研究临床案例研究
背景情况:
- 诺卡迪亚 pseudobrasiliensis是一种新兴的人类病原性诺卡迪亚物种.
- 它与Nocardia brasiliensis具有共同的形态特征,但更具入侵性和传播性.
- N. pseudobrasiliensis hydrarthrosis之前没有被描述过.
研究的目的:
- 报告Nocardia pseudobrasiliensis hydrarthrosis的第一个临床病例.
- 详细介绍这种罕见感染的诊断过程,治疗和预后.
- 为了比较N. pseudobrasiliensis分离物与N. brasiliensis的抗生素敏感性.
主要方法:
- 在江省人民医院接受治疗的患者的案例分析.
- 磁共振成像 (MRI) 用于关节溢出和软组织评估.
- 关节液的油显微镜用于酸-快-阳性纤维.
- 用于病原体识别的矩阵辅助激光脱吸电离时间飞行质谱学 (MALDI-TOF MS).
主要成果:
- 核磁共振扫描显示了关节溢出和软组织胀.
- 油脂显微镜发现了丰富的酸-快-阳性纤维.
- 马尔迪-托夫医院的医生证实了病原体是诺卡迪亚 pseudobrasiliensis.
- 与N.brasiliensis不同的是,N.pseudobrasiliensis分离物对西普罗夫洛克萨完全敏感.
结论:
- 这是第一个报告的Nocardia pseudobrasiliensis病例,导致水.
- 尼古拉菌表现出明显的临床和微生物特征.
- 了解其独特的抗生素敏感性对于有效治疗至关重要.
相关概念视频
Autoimmune Disorders
447
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
447
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
168
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
168
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
142
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
142
Inflammatory Bowel Disease II: Crohn's Disease
253
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
253
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
121
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
121
Psychoneuroimmunology: Cardiovascular Disease
31
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
31


