多囊卵巢综合征和孕前风险:基于国家登记的队列研究
Ragnheidur Valdimarsdottir1, Eszter Vanky2,3, Evangelia Elenis1
1Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
BJOG : an international journal of obstetrics and gynaecology
|December 12, 2023
概括
患有多囊性卵巢综合征 (PCOS) 的女性患有先兆子的风险更高,特别是早期发病的先兆子和先兆子,如果婴儿小于妊娠年龄. 这项研究无法证实过高雄性恋是否影响了这一关联.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 流行病学 流行病学
背景情况:
- 多囊卵巢综合征 (PCOS) 是一种常见的内分泌疾病.
- 结核复合综合症与不良妊娠结果有关,包括先兆子.
- 在PCOS相关的孕前症中,高雄性特征的作用需要进一步研究.
研究的目的:
- 为了调查PCOS和子宫前之间的关联.
- 为了确定是否治疗的临床高雄性异能症改变了PCOS与前性结核的联系.
- 为了检查PCOS是否与特定的妊娠前亚型有关.
主要方法:
- 在瑞典进行全国范围的基于登记的队列研究.
- 包括从1997年至2015年期间患有PCOS的女性 (n=22,947) 和对照组 (n=115,272) 的女性.
- 使用条件后勤回归来估计子宫前的几率比率,调整为混因素.
主要成果:
- 患有PCOS的女性患有妊娠前的风险增加了29% (aOR为1.29,95%CI为1.20-1.39).
- 在接受过多雄激素治疗的和未接受过多雄激素治疗的女性中,PCOS与子前症的关联性相似.
- 结核复合综合症与早期妊娠前 (aOR 1.64) 更强烈地相关,以及与妊娠年龄较小的婴儿发生妊娠前.
结论:
- 患有PCOS的女性患有先兆子的风险较高,特别是早期发病和SGA相关的形式.
- 目前的数据无法在PCOS中建立高雄性和先兆子之间的联系.
- 需要进一步的研究来阐明PCOS相关的先兆子背后的机制.
相关概念视频
Oogenesis
63.7K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.7K
Pathophysiology of Diabetes
949
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
949
Diabetes Mellitus: Type 2 and Gestational
2.4K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.4K
Ovarian Cycle
1.3K
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
1.3K
Disorders of the Female Reproductive System
366
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
366


