gPKPDviz:使用mrgsolve进行药理动力学/药理动力学模拟的灵活R闪亮工具
Tong Lu1, Victor Poon1, Logan Brooks1
1Department of Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.
CPT: pharmacometrics & systems pharmacology
|December 12, 2023
概括
GPKPDviz是一个开源的Shiny应用程序,用于实时的药理动力学/药理动力学 (PK/PD) 模型模拟和可视化. 它有助于有效评估临床药理学PK/PD终点上的共变量和剂量.
科学领域:
- 制药指标 (Pharmacometrics) 是一个指标.
- 临床药理学 临床药理学
- 计算生物学 计算生物学
背景情况:
- 药理动力学/药理动力学 (PK/PD) 建模对于药物开发至关重要.
- 需要有效的工具来模拟和可视化PK/PD模型.
- 现有的工具在处理复杂的剂量和人口数据时可能缺乏灵活性.
研究的目的:
- 介绍GPKPDviz,一个用于实时PK/PD模型模拟和评估的闪亮应用程序.
- 为评估共变量和剂量方案对PK/PD终点的影响提供简化的工作流程.
- 为了使用mrgsolve引擎实现群体和个人PK/PD模拟.
主要方法:
- 作为一个 Shiny 应用程序使用 mrgsolve 模拟引擎开发.
- 包含用于生成虚拟人群,复杂的剂量/采样场景和加载临床试验数据的功能.
- 包括一个内置的文本编辑器与调试对 mrgsolve 模型.
- 通过将模拟结果与rgsolve in R. 的结果进行比较来验证.
主要成果:
- GPKPDviz可以实时模拟和可视化PK/PD模型.
- 该应用程序支持复杂的剂量方案 (单次,多次,负载,间歇) 和共变量分析.
- 它可以使用外部数据集进行人口模拟和个人模拟.
- 严格的验证证实了模拟结果的准确性.
结论:
- GPKPDviz是药量学界的一个有价值的开源工具.
- 它提高了在临床药理学中PK/PD建模和模拟的效率.
- 该应用程序有助于更深入地了解药物行为和影响.
相关概念视频
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