黑色素作为骨中的一种时代生物/细胞保护剂. 涉及的剂量包括:
1CENECON, Faculty of Medical Sciences, Universidad de Buenos Aires, Buenos Aires, Argentina.
Journal of pineal research
|December 12, 2023
概括
Melatonin 是一个随着年龄的增长而减少的分子,它保护骨细胞,并可能防止骨质流失. 需要进一步的研究来探索更高的剂量,以获得更大的骨健康治疗效果.
科学领域:
- 时间生物学 时间生物学
- 骨生物学 骨生物学 骨生物学
- 老年学是一门学科.
背景情况:
- 随着年龄的增长,黑色素水平下降,影响了绝经后和衰老病理.
- 骨头是通过MT1和MT2受体对黑激素的时代生物效应的目标部位.
- 黑色素可能会在骨髓前体上充当细胞保护性autacoid.
研究的目的:
- 研究黑激素在骨健康中的作用,特别是在老化和绝经后的个体中.
- 探索黑激素对骨细胞的影响,包括骨质母细胞和骨质母细胞.
- 为了评估黑激素的潜力,包括更高的剂量,在预防骨质损失.
主要方法:
- 对有关黑激素对骨影响的现有文献的综述.
- 对黑激素对骨细胞前体和矩阵蛋白质 (如公原I型c-) 的影响的分析.
- 检查黑素对骨质保护素和骨质细胞活性的影响.
- 考虑黑激素与骨再吸收有关的自由基清除特性.
主要成果:
- 黑色素暴露会增加骨基质蛋白和骨质保护素,这是一个抑制骨质细胞分化的抑制剂.
- 黑色素通过其自由基清除特性损害骨质细胞活性和骨再吸收.
- 目前的临床研究往往使用较低的黑激素剂量比动物研究中的全米导数所建议的.
结论:
- 黑素显示出作为骨细胞的细胞保护剂的潜力,并可能抑制骨质再吸收.
- 较高剂量的黑激素,在临床上不常用,需要进一步的研究,以提高治疗疗效,防止骨质损失.
- 在高剂量研究中缺乏毒性表明,有可能在骨健康干预中探索更高的黑激素剂量.
关键词:
所有度测法 (allometry) 是一种全度测法.骨生理学 骨生理学时代生物生物的时间生物.昼夜节律是指昼夜节律的节奏.细胞保护剂 细胞保护剂黑激素是什么意思 黑激素是什么意思骨质疏松症是一种骨质疏松症.氧化应激是一种氧化应激.更多相关视频
11:47A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
Published on: June 8, 2014
11.7K
12:02Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption
Published on: July 30, 2016
15.9K
相关概念视频
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
64
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
64
01:19Management of Insomnia
255
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
255
01:29Bone Disorders
3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
01:17Sedatives and Hypnotics Drugs: Miscellaneous Agents
179
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
179
01:40Bone Remodeling
38.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.3K
01:31Essential Minerals for Bone Health
4.0K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
4.0K