跨身体质量指数组的孕产妇代谢概况:一项探索性纵向研究
Hege Nyhus Skytte1,2, Marie Cecilie Paasche Roland3, Jacob Juel Christensen4
1Norwegian Research Center for Women's Health, Oslo University Hospital, Oslo, Norway.
Acta obstetricia et gynecologica Scandinavica
|December 12, 2023
概括
超重或肥胖的孕妇在怀孕初期表现出明显的代谢特征,包括更高的脂质和分支链氨基酸. 孕期体重增加并没有显著改变这些代谢差异.
科学领域:
- 产科和妇科 产科和妇科
- 代谢健康 代谢健康
- 怀孕研究 怀孕研究
背景情况:
- 增加的体重指数 (BMI) 是已知的妊娠并发症风险因素.
- 关联BMI与不良妊娠结果的潜在代谢因素在很大程度上是未知的.
研究的目的:
- 为了在怀孕期间比较超重/肥胖和正常体重/体重不足的女性之间的代谢概况.
- 为了研究妊娠期体重增加 (GWG) 对整个妊娠期母亲代谢概况的影响.
主要方法:
- 在107名女性 (48名超重/肥胖,59名正常体重/体重不足) 进行的探索性嵌套病例控制研究.
- 在四个妊娠时间点使用核磁共振光谱分析的等离子体样本.
- 量化91种代谢物,包括脂质,脂肪酸和氨基酸.
主要成果:
- 超重/肥胖妇女在怀孕早期表现出更高水平的极低密度脂蛋白 (VLDL) 脂质,甘油三和分支链氨基酸 (白,氨酸).
- 在怀孕后期超重/肥胖妇女中观察到较低的多可萨赫萨埃诺酸和不和度.
- 在多个时间点,在超重/肥胖女性中发现了较高的XXL-VLDL颗粒度和糖蛋白乙 (GlycA).
结论:
- 与正常体重/体重不足的女性相比,超重/肥胖女性的怀孕相关代谢变化不那么明显.
- 趋势表明,超重/肥胖个体的甘油三和VLDL颗粒度较高.
- 这些发现需要进一步调查与子宫前的联系以及脂肪酸成分改变对后代的影响.
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