印度尔-3-降低炎症反应并恢复肠上皮质屏障功能,部分通过实验性结肠炎模型中的阿里尔碳水化合物受体 (AhR)
Mu Wang1,2, Jian Guo3, Ailsa L Hart4
1Section of Nutrition, Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, W12 0NN, UK.
Journal of inflammation research
|December 12, 2023
概括
印度醇-3-化物 (IAld) 降低了肠道炎症,并改善了结肠炎模型中的肠道屏障功能,部分是通过激活酸碳化合物受体 (AhR). 这种化合物为炎症性肠道疾病提供了潜在的治疗策略.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 众所周知,在小鼠结肠炎模型中,英多尔-3-化物 (IAld) 通过阿里碳水化合物受体 (AhR) 增强肠上皮屏障 (IEB) 功能.
- IAld对肠道组织炎症及其潜在机制的具体影响仍然在很大程度上未被探索.
研究的目的:
- 在体内和体外研究IAld对肠道炎症反应的影响.
- 阐明IAld减轻结肠炎的机制,重点关注AhR激活和炎症途径.
主要方法:
- 评估IAld对表型变化,促炎性细胞因子 (IL-6,IL-1β,TNF-α),IEB功能以及硫酸 (DSS) 诱导的大肠炎小鼠便细菌组成的影响.
- 在体外模型中使用脂聚糖 (LPS) 刺激的巨细胞和肠上皮细胞来测量IAld对炎症和IEB功能的影响.
主要成果:
- IAld在结肠组织和LPS刺激的巨细胞中显著降低了IL-6,IL-1β和TNF-α水平.
- 通过IAld介导的IL-6的降低,但不是IL-1β或TNF-α,取决于AhR激活.
- IAld通过AhR激活抑制了核因子-κB通路,并通过降低酸化肌素光链的调节改善了肠道透性.
- 尽管炎症减少,但没有观察到IAld对便细菌组成的显著影响.
结论:
- IAld通过抑制炎症反应和恢复IEB功能来改善DSS诱导的大肠炎,通过AhR激活部分调解.
- IAld显示出作为调节肠道炎症和改善肠道屏障完整性的治疗剂的潜力.
更多相关视频
相关概念视频
Drugs for Treatment of Ulcerative Colitis in IBD
145
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
145
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
335
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
335
Inflammatory Response
2.0K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.0K
Inflammatory Bowel Disease IV: Pharmacological Management
129
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
129
Drugs for Treatment of Diarrhea-Predominant IBS
179
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
179
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
121
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
121


