从可吸入的酸盐/卡拉基南微球中释放的异化的特征和释放
Yotomi Desia Eka Rani1, Mahardian Rahmadi2, Dewi Melani Hariyadi1,3
1Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Campus C Mulyorejo, Surabaya, 60115, Indonesia.
Therapeutic delivery
|December 12, 2023
概括
新的异化物可吸入微球为结核病治疗提供有针对性的肺部输送. 这些基于聚合物的微球显示出有希望的药物加载和释放特征,以改善结核病治疗.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 肺部医学 肺部医学
背景情况:
- 结核病 (TB) 治疗面临着当前治疗方法的局限性.
- 需要有针对性的药物输送系统来提高治疗效率和克服挑战.
- 吸入式微球是直接向肺部输送抗结核病药物的有希望的策略.
研究的目的:
- 开发和描述异化物可吸入微球,用于针对性结核病治疗.
- 评估基于聚合物的微球在肺部药物输送方面的潜力.
- 评估开发的微球的药物载荷,捕获效率和释放动力学.
主要方法:
- 易索尼亚的可吸入微球是使用离子热凝方法制备的.
- 在四种不同的配方中采用了酸盐,卡拉基南和化.
- 分析了粒子大小,形态,流动性,药物加载,捕获效率和药物释放.
主要成果:
- 微球呈现出光滑的球形形态,颗粒大小小小于5微米,具有良好的流动性.
- 毒品负载在1.69%至2.75%之间,捕获效率在62.44%至85.30%之间.
- 药物释放动力学遵循Korsmeyer-Peppas模型,表明了Fickian扩散.
结论:
- 伊索尼亚齐德可吸入的微球成功地被开发为肺部的向输送系统.
- 这些微球显示了通过直接肺部注射改善结核病治疗的潜力.
- 这些发现支持使用可吸入的微球来有效治疗结核病.
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