对前额叶皮层进行的跨直流刺激可以增强工作记忆,并抑制精神分裂症患者病理性马功率升高
Oded Meiron1,2, Asaf Yaniv2, Sylvie Rozenberg3
1The Faculty of Education, Bar-Ilan University, Ramat Gan, Israel.
Expert review of neurotherapeutics
|December 12, 2023
概括
跨直流刺激 (tDCS) 改善了精神分裂症患者的工作记忆 (WM) 并减少了症状. 这种神经刺激技术有望提高认知功能,并提供一种潜在的新型治疗策略.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 精神分裂症 (SZ) 与工作记忆 (WM) 功能障碍有关.
- 前额叶皮层跨直流刺激 (tDCS) 正在作为SZ认知缺陷的治疗方法进行研究.
研究的目的:
- 检查前额叶皮层tDCS对慢性精神分裂症患者工作记忆 (WM) 功能障碍的临床益处.
- 评估tDCS对SZ患者症状严重程度和休息电脑电图 (EEG) 的影响.
主要方法:
- 一项随机对照试验涉及34名精神分裂症患者,其中29人被随机分配到活跃或假的tDCS.
- tDCS干预包括5天的10次会议 (20分钟,2mA,每天两次).
- 评估包括WM表现,症状严重程度和休息EEG,并对症状严重程度进行12周的随访.
主要成果:
- 与假冒的tDCS相比,主动的tDCS显著提高了WM准确性.
- 在活动tDCS后一周观察到症状严重程度的显著降低.
- 活跃的tDCS导致持续的静止马稳定性 (RGS),而假的tDCS显示病理性马功率增加.
结论:
- tDCS可能是一个可行的策略,通过促进左DLPFC刺激性来增强精神分裂症中WM功能.
- 对RGS的治疗效果的监测可以确定有效的新型治疗方法.
- 需要进一步的研究来确认长期的临床益处.
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