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Updated: Jul 8, 2025

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在人类呼吸道光滑肌细胞中,TNFα诱导的线粒体分裂背后的分子机制

Debanjali Dasgupta1, Sanjana Mahadev Bhat1, Claire Creighton1

  • 1Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States.

American journal of physiology. Lung cellular and molecular physiology
|December 12, 2023
PubMed
概括

瘤亡因子α (TNFα) 诱导呼吸道光滑肌细胞内质网膜应激,导致线粒体分裂. 这一途径涉及pIRE1α/XBP1s激活CDK1/5,后者酸化DRP1,导致碎片化.

关键词:
DRP1的酸化方式压力ERER压力ERER压力呼吸道炎症 呼吸道炎症呼吸道平滑肌肉的肌肉.线粒体碎片化的分裂

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