非洲祖先种群中的多病性:一个范围审查
Michelle Kamp1,2, Okechinyere Achilonu2, Isaac Kisiangani3
1Division of Human Genetics, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
BMJ global health
|December 12, 2023
概括
多发病 (MM) 影响全球非洲祖先人口,心血管和代谢疾病是最常见的. 需要更多的研究来了解和改善这些不同群体的医疗保健.
科学领域:
- 全球健康 全球健康
- 流行病学 流行病学
- 医学研究 医学研究
背景情况:
- 多发病 (MM) 在全球范围内带来了重大的健康挑战和医疗保健成本.
- 现有的MM研究主要集中在欧洲祖先的种群上,留下了重要的知识差距.
- 非洲祖先群体中MM的流行率和模式,无论是在非洲大陆还是民中,都未被充分探索.
研究的目的:
- 识别和综合有关非洲血统人口多病症 (MM) 的现有文献.
- 探索非洲大陆及其民中的MM的流行和模式.
- 突出研究差距,并为未来有关MM在这些人群中的研究提供信息.
主要方法:
- 2022年7月,对五个主要学术数据库进行了全面的范围审查.
- 选择了2010年至2022年6月期间发表的研究,重点关注非洲祖先群体中的MM.
- 采用数据提取和叙事合成来总结有关方法和关键主题的发现.
主要成果:
- 审查确定了232篇关于非洲祖先群体MM的出版物,检查了大陆 (113),民 (100) 和两种 (19) 种群.
- 心血管和代谢疾病占主导地位 (80%的大陆,70%的民),而传染病在大陆研究中更常见 (58%).
- 相关因素包括年龄较大,女性性别和较低的社会经济地位,在数据,代表性,方法和翻译研究方面发现了研究缺口.
结论:
- 多种疾病是非洲祖先人口日益关注的问题,反映了全球趋势.
- 了解非洲祖先人口的独特背景对于解决MM负担至关重要.
- 进一步的研究对于指导和加强全球非洲祖先人口的医疗保健策略至关重要.
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