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在双相情绪障碍中,大脑功能变化跨越情绪状态:从大规模网络视角来看
Yan-Kun Wu1, Yun-Ai Su1, Le Li2,3
1Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China.
Psychological medicine
|December 12, 2023
概括
双极性障碍 (BD) 涉及在躁狂状态期间改变大脑网络连接,特别是默认模式网络 (DMN). 这些变化与躁狂严重程度相关,为BD提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 脑部成像 脑部成像
背景情况:
- 了解情绪状态的神经基础对于双相情绪障碍 (BD) 病理生理学至关重要.
- 关于BD情绪切换的研究是有限的和不一致的.
研究的目的:
- 为了调查大规模的大脑网络功能连接 (FC) 在双相情绪障碍情绪状态之间的差异.
- 为了将这些网络变化与临床特征相关联.
主要方法:
- 休息状态的fMRI数据来自162名BD患者 (躁狂,舒缓,抑郁) 和80名健康对照 (HCs).
- 大规模大脑网络FC和拓节点属性的比较.
- 使用小型纵向样本 (n=11) 进行验证.
主要成果:
- 与HC和其他BD状态相比, (低) 躁狂患者表现出加强的网络FC,特别是涉及默认模式网络 (DMN),与HC和其他BD状态相比.
- 增加DMN和腹部注意力/边缘网络之间的FC与 (低) 躁狂严重程度和积极影响相关.
- 双极性抑郁症患者在边缘网络 (LN) 中表现出降低的FC.
结论:
- 在双相情感障碍中确定了 (低) 躁狂症中大规模网络干扰的独特模式.
- 这些发现增强了对 BD 情绪状态背后的神经机制的理解.
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