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Updated: Jul 8, 2025

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使用单细胞多原子数据绘制高分辨率的高分辨率 cis-regulatory 电路映射.

Zidong Zhang1,2, Frederique Ruf-Zamojski1, Michel Zamojski1

  • 1Department of Neurology, Center for Advanced Research on Diagnostic Assays, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY, USA.

Nucleic acids research
|December 12, 2023
PubMed
概括

一个新的框架CREMA,利用单细胞多基因组数据绘制细胞特异性基因调节的地图. 它确定了其他方法遗漏的调节元素,揭示了关键的细胞类型区别和基因电路.

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相关概念视频

Cis-regulatory Sequences02:02

Cis-regulatory Sequences

Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
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