相关实验视频

Updated: Jul 8, 2025

Synthesis of Immunotargeted Magneto-plasmonic Nanoclusters

Synthesis of Immunotargeted Magneto-plasmonic Nanoclusters

Published on: August 22, 2014

针对EGFR向的纳米纤维的ROS介导的抗癌作用

Kochurani K Johnson^1,2, Pramod Koshy¹, Chantal Kopecky³

¹School of Materials Science and Engineering, Faculty of Science, UNSW Sydney, Sydney, New South Wales, Australia.

Journal of biomedical materials research. Part A

|December 12, 2023

概括

用EGF功能化的菌纳米棒对表皮生长因子受体 (EGFR) 的积极向可以提高抗癌药物递送和对肉瘤细胞的有效性. 这一策略改善了细胞吸收和治疗性能.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
在瘤学瘤学.

背景情况:

通过使用活性受体向策略,可以提高抗癌药物的疗效.
皮表皮生长因子受体 (EGFR) 是各种类型的肉瘤的一个关键生物标志物.

研究的目的:

为了研究化和EGF功能化的Ceria纳米棒的体外生物医学特性.
评估这些纳米棒在肉瘤治疗中的EGFR向效率和治疗效果.

主要方法:

合成和表征化和EGF功能化的米纳米棒.
在体外受体结合研究以证实EGFR向.
在HT-1080纤维素瘤和MRC-5细胞中评估细胞吸收,反应性氧物种 (ROS) 生产和细胞毒性.
显微镜技术 (TEM,共聚焦) 用于吸收确认.

主要成果:

通过EGFR向,EGF功能化的纳米纤维体表现出HT-1080纤维瘤细胞通过EGFR向增强细胞吸收.
与化版本相比,在EGF功能化的纳米中观察到细胞毒性和ROS产量的增加.
化纳米最初对健康细胞具有极小的细胞毒性,但在72小时后具有显著的积累诱导毒性.
在所有测试时间点上,癌细胞都表现出来自纳米的相当大的细胞毒性.

结论:

向EGFR显著增强癌细胞中纳米纤维的吸收,提高治疗性能.
用EGF功能化的菌纳米棒显示出作为治疗肉瘤的有效抗癌纳米药物的潜力.
纤维细胞催化,细胞碎片和活性部位阻塞之间的平衡影响ROS生成和细胞毒性.

关键词:

欧洲农业基金会 (EGFR) 是一个基金.这就是ROSOS ROS.癌症癌症癌症癌症癌症纳米纤维的使用方法有针对性的治疗.

更多相关视频

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

Therapeutic Gene Delivery and Transfection in Human Pancreatic Cancer Cells using Epidermal Growth Factor Receptor-targeted Gelatin Nanoparticles

Therapeutic Gene Delivery and Transfection in Human Pancreatic Cancer Cells using Epidermal Growth Factor Receptor-targeted Gelatin Nanoparticles

Published on: January 4, 2012

相关概念视频

Mitogens and the Cell Cycle

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...