在儿科患者中SARS-CoV-2Omicron变异的病毒动态:一项前性队列研究
Michelle Science1,2,3, Julia Orkin3,4,5, Bryan Maguire6
1Division of Infectious Diseases, Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada.
概括
患有严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 的儿童在症状消失后的第二天经常达到非传染性病毒载荷水平. 快速抗原测试 (RATs) 在疾病早期可能不可靠,这强调了对儿科SARS-CoV-2动态的进一步研究的需要.
科学领域:
- 儿童传染病 儿童传染病
- 病毒学 病毒学
- 流行病学 流行病学
背景情况:
- 关于儿童严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 病毒动态的数据有限.
- 了解儿科人群中的病毒载量和流放对于感染控制和公共卫生战略至关重要.
研究的目的:
- 调查感染SARS-CoV-2的儿童的病毒动态,包括病毒载量和流放时间.
- 为公众健康和感染控制决策提供有关小儿SARS-CoV-2传播的信息.
主要方法:
- 在101名儿童 (2-17岁) 的前性队列研究中,PCR确认了SARS-CoV-2.
- 每天进行10天的病毒载荷测试,其中一个子集完成了每日快速抗原测试 (RAT).
- 使用Cox比例危险模型对病毒RNA轨迹相对于症状发作和解决的分析.
主要成果:
- 非传染性病毒载荷的中位时间是症状出现后的5天;75%的患者在7天内实现了这一目标.
- 49%和60%的患者在症状消失之日和症状消失后的第二天分别达到非传染性值.
- 快速抗原测试 (RATs) 显示出可变的阳性,在非传染性病毒载荷的第一天,61%的阳性.
结论:
- 患有SARS-CoV-2的儿童在症状消失后不久经常达到非传染性病毒载荷值.
- 快速抗原测试 (RATs) 可能在疾病早期产生假阴性结果,不应仅仅依赖于排除感染.
- 需要进一步的研究,以充分阐明儿科SARS-CoV-2病毒动态,并优化诊断和控制措施.
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