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在Drosophila melanogaster中探索寒冷和免疫应激之间的交叉保护作用

Jakob Wiil¹, Jesper Givskov Sørensen², Hervé Colinet¹

¹Université de Rennes, CNRS, ECOBIO [(Écosystèmes, biodiversité, évolution)] - UMR 6553, 263 AVE du Général Leclerc, 35000 Rennes, France.

Parasite (Paris, France)

|December 12, 2023

概括

昆虫的应激反应涉及寒冷和病原体之间的复杂相互作用. 结合的压力因素协同激活turandot基因,揭示了Drosophila melanogaster中复杂的交叉耐受性机制.

科学领域:

* 昆虫生理学和应激反应.
*环境毒理学和免疫学.
*分子生物学和基因表达.

背景情况:

* 环境和生物压力因素极大地影响了ectotherm生命周期.
* 在昆虫中,寒冷应激和病原体感染之间存在复杂的相互作用和潜在的交叉保护机制.
* 昆虫的应激反应表现出广泛的连接性,需要对候选基因 (如turandot) 进行研究.

研究的目的:

* 为了研究寒冷压力和Drosophila melanogaster寄生真菌感染之间的相互作用的功能意义.
* 评估新发现的turandot基因在调解这些压力反应中的作用.
* 确定联合应激因素暴露的表型和分子结果.

主要方法:

*因子实验使得Drosophila melanogaster暴露于急性或慢性感冒压力,并与Beauveria bassiana感染相结合.
*评估诱导的耐寒性和对真菌感染的免疫抵抗力.
* 在各种压力条件下测量turandot基因表达模式.

主要成果:

*表型结果各不相同,寒冷压力增加了感染易感性,但感染增加了急性感冒生存率.
* 图兰多特基因在对个人和联合压力因素的反应中过度表达.
* 结合感染和感冒治疗对turandot基因表达峰值产生显著的协同效应.

结论:

* 昆虫对感染和非生物压力的反应非常复杂.
* 图兰多特基因在调解对感冒和感染的反应中发挥着重要作用.
*turandot基因的协同激活突出了昆虫应激反应途径中复杂的交叉耐受机制.

关键词:

生物压力是生物压力.交叉谈话 / 宽容这种植物是Drosophila melanogaster.压力反应应对压力.图兰多特基因是基因中的一个.

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