通过全基因组测序揭示了两种Schistosoma japonicum分离物与对比的cercarial脱落模式之间的遗传差异

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Updated: Jul 8, 2025

Isolation and Characterization of Extracellular Vesicles from Adult Schistosoma japonicum

Isolation and Characterization of Extracellular Vesicles from Adult Schistosoma japonicum

Published on: May 22, 2018

Hui-Ying Sun¹, Jie-Ying Zhang¹, Han-Xiang Zhang¹

¹Department of Epidemiology and Statistics, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, 199 RenAi Road, Industrial Park Avenue, Suzhou, Jiangsu 215123, PR China.

Parasite (Paris, France)

|December 12, 2023

概括

对Schistosoma japonicum的遗传分析显示,在丘陵和沼泽地区的孤立群体中,有明显的适应性. 丘陵的分离物体在选择过程中显示出较少的基因组区域,但具有与DNA结合和信号传递相关的关键基因,这可能解释了其独特的出现模式.

科学领域:

基因组学就是基因组学.
寄生虫学的寄生虫学
进化生物学进化生物学

背景情况:

日本螺旋虫 (Schistosoma japonicum) 引起人类螺旋虫病,在亚洲是特有病.
之前的研究指出,体隔离物中存在不同的体出现模式.
这些适应性特征的遗传基础仍然没有通过全基因组测序进行调查.

研究的目的:

为了研究 Schistosoma japonicum 分离物中适应性特征的遗传基础.
为了比较山地和沼泽地石瘤种群之间的基因组变异和选择信号.
为了识别与特定的cercarial出现模式相关的基因.

主要方法:

在中国安的山地 (ST) 和沼泽地 (HX) 地区的成年Schistosoma japonicum虫的全基因组测序 (2013年,2020年).
对遗传差异化的分析和对全基因组的选择信号的检测.
精选基因组区域的基因丰富分析.

主要成果:

在ST和HX分离物之间观察到显著的遗传差异化.
沼泽地 (HX) 隔离物表现出更多的基因组区域在选择 (318个窗口,276个基因) 与山地 (ST) 隔离物 (64个窗口,78个基因) 相比.
在ST分离物中发现了12个显著丰富的基因,主要涉及DNA结合和细胞间信号传递,在ST分离物中发现了12个显著丰富的基因.

结论:

Schistosoma japonicum分离物的遗传构成因其环境而有显著差异.
丘陵孤立的基因组显示出选择的证据,特定的基因可能与其独特的下午晚些时候的cercarial出现有关.
这些发现为 Schistosoma japonicum 的进化适应提供了洞察力.

关键词:

一个特定的出现模式.遗传差异化基因差异化在日本,它被认为是Schistosoma japonicum.整个基因组的测序.

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