周期值预测COVID-19的严重程度和死亡率,但与实验室标记物无关
Behnaz Esmaeili1, Hoda Khoshnevis2, Atefe Alirezaee3
1Department of Basic Medical Sciences, Khoy University of Medical Sciences, Khoy, Iran. esmaeilib2@gmail.com.
Iranian journal of allergy, asthma, and immunology
|December 12, 2023
概括
周期值 (Ct) 值可以预测2019年新冠肺炎 (COVID-19) 疾病的严重程度. 严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染患者的Ct值较低表明危急疾病和较高的死亡风险.
科学领域:
- 病毒学 病毒学
- 传染性疾病 传染性疾病
- 临床医学 临床医学
背景情况:
- 在重症急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 测试中的周期值 (Ct) 值被探索用于预测冠状病毒疾病2019 (COVID-19) 严重程度.
- 之前的研究对Ct值的有用性产生了不一致的结果.
研究的目的:
- 评估SARS-CoV-2 Ct值与COVID-19疾病严重程度,炎症标志物和伊朗住院患者的患者结果之间的关联.
主要方法:
- 在2020年9月至2021年10月期间住院的528名COVID-19患者的回顾性分析.
- Ct值被分为低 (<20),中等 (20-30),高 (>30).
- 分析了人口,临床和实验室数据.
主要成果:
- 低CT值的患者患有危急COVID-19的可能性更高,侵入性机械通风,以及ARDS和肺炎等并发症.
- 与高Ct值相比,低或中Ct值与死亡风险增加有关.
- 多变量分析证实低/中Ct值是严重COVID-19的预测因素,并表明低Ct值患者死亡风险更高的趋势.
结论:
- SARS-CoV-2 Ct值是COVID-19严重程度的独立预测指标.
- 较低的Ct值与死亡风险增加有关.
- 需要进一步的研究来探索Ct值和炎症因素之间的相关性.
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