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在炎症性肠病患者中长非编码RNA-MALAT1和介质素-6的表达分析

Mohsen Nemati Bajestan¹, Moein Piroozkhah², Vahid Chaleshi³

¹Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Centre, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. mohsen13.nemati@gmail.com.

Iranian journal of allergy, asthma, and immunology

|December 12, 2023

概括

转移相关的肺腺癌转录1 (MALAT1) 和干白素-6 (IL6) 在炎症性肠病 (IBD) 中表达升高. 这些分子可以作为IBD的诊断和治疗点.

科学领域:

分子生物学分子生物学
免疫学免疫学免疫学
胃肠病学胃肠病学

背景情况:

炎症性肠病 (IBD) 涉及慢性胃肠道炎症.
长非编码RNA (lncRNA) MALAT1的错误调节与自身免疫性疾病有关.
互白素-6 (IL6) 在像IBD这样的免疫触发性炎症状况中起着关键作用.

研究的目的:

在IBD患者中分析MALAT1和IL6的表达.
在IBD的背景下调查MALAT1和IL6之间的潜在相互作用.
为了确定IBD的潜在治疗点.

主要方法:

定量实时聚合酶连锁反应 (qPCR) 用于基因表达分析.
构建一个具有竞争力的内源RNA (ceRNA) 监管网络.
数据库分析 (炎症性肠病数据库,DGIdb) 用于基因功能和药物发现.

主要成果:

与健康对照组相比,IBD患者观察到MALAT1和IL6的表达升高.
IL6可能充当MALAT1的标,其相互作用由特定的微RNA (hsa-miR-202-3p,hsa-miR-1-3p,has-miR-9-5p) 介导.
确定了潜在的治疗药物,CILOBRADINE用于MALAT1和SILTUXIMAB用于IL6.

结论:

马拉特1和IL6是IBD诊断的潜在生物标志物.
针对MALAT1和IL6是一个有前途的IBD治疗策略.
对监管网络和治疗潜力的进一步研究是有必要的.

关键词:

克罗恩氏病是什么克罗恩氏病是什么基因监管网络是基因监管网络.炎症性肠疾病炎症性肠病介乐金-6 介乐金-6 是一种马拉特1长非编码RNA,人类性结肠炎是一种

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