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自从前坎布里亚时代以来,在各种动物中保存的DNA控制着胚胎发育的基因

Martin C Frith^1,2,3, Shengliang Ni²

¹Artificial Intelligence Research Center, AIST, Tokyo, Japan.

Molecular biology and evolution

|December 12, 2023

概括

研究人员在各种动物群体中发现了保存的调节性DNA序列,揭示了动物发育的古代遗传控制. 这一发现揭示了早期动物进化的深层同质性.

科学领域:

发展生物学发展生物学
进化遗传学进化遗传学
进行比较基因组学.

背景情况:

调节性DNA,如增强剂和促进剂,控制基因表达通常不会在与之相近的动物族群中保存.
"深层同源性"的概念认为,具有类似复杂表达模式的同源基因组织了动物的发育,但基本的保存调节DNA在很大程度上仍然难以捉摸.
这种保护差距在动物中保存的发育模式的遗传基础上呈现了一个.

研究的目的:

在广泛的双边动物中识别和表征保存的调节性DNA段.
为了调查这种保存元素在更遥远的相关科目中存在的情况,如cnidaria.
了解动物发育中保存的基因调控元素的进化历史和功能意义.

主要方法:

对各种动物类的基因组进行比较基因组学分析,包括双胞胎和类动物.
序列对齐和保存的非编码DNA片段的识别.
生物信息分析以确定这些细分市场中保存的监管动机 (例如,CCAAT盒,E-盒).
保存细分与关键发育基因的关联,包括homeobox基因.

主要成果:

在双边动物中保存的25个调节性DNA段的识别.
发现了7个这些细分也保存在cnidaria (例如,珊瑚,海).
这些受保护的部分调节了关键的发育基因,包括六个homeobox基因 (Gsx,Hmx,Meis,Msx,Six1/2,Zfhx3/4) 和其他如Nr2f,Ptch,Rfx1/3,Sall,Smad6,Sp5,Tbx2/3.3.
保存的细分包含高度保存的调节动机,被转录因子识别出来.

结论:

动物基因调节DNA控制发育的很大一部分在漫长的进化距离中被保存下来,可以追溯到前坎布里亚时代.
这一发现揭示了一个古老的,保存的基因控制系统,是动物发育和深层同源性的基础.
未来的基因组研究和优化序列比较预计将揭示额外的保留调节元素,进一步阐明早期动物进化.

关键词:

这就是Evo-devo的意思.同源性同质性是一致性.转录转录是一种转录.

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