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麻症及其各个组成部分是否与心力衰竭的全因死亡率有关? 一个系统的审查和元分析
Konstantinos Prokopidis1, Konstantinos Katsikas Triantafyllidis2, Konstantinos Spyridon Kechagias3
1Department of Musculoskeletal Ageing and Science, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK. k.prokopidis@liverpool.ac.uk.
概括
像低肌肉质量和缓慢步行速度这样的sarcopenia成分显著预测心力衰竭 (HF) 患者的死亡率. 早期对身体功能进行干预可能会降低HF患者过早死亡的风险.
科学领域:
- 心脏病学 心脏病学
- 老年病的医生 老年病的医生
- 肌肉生理学 肌肉生理学
背景情况:
- 心力衰竭 (HF) 是一种复杂的疾病,与死亡率的增加有关.
- 骨肌肉质量和功能的损失 - - 萨科佩尼亚 - - 在老年人中很普遍,可能会影响HF预后.
- 了解肉症及其组成部分的预后作用对于改善患者的治疗结果至关重要.
研究的目的:
- 在心力衰竭 (HF) 患者中,系统地审查和元分析缩症及其组成部分的预后价值.
- 确定与皮病相关的特定因素,这些因素可以预测高频率患者的全因死亡率.
主要方法:
- 从创立到2022年12月,对主要数据库 (PubMed,科学网,Scopus,Cochrane图书馆) 进行了系统的文献搜索.
- 随机效应模型被用于元分析,以汇集来自18项纵向研究的数据.
- 对于那些未被纳入元分析的研究,使用了叙事综合.
主要成果:
- 低L3-L4 psoas肌肉质量 (HR: 2.20) 和缓慢的步行速度 (HR: 1.45) 是HF患者全因死亡率的显著预测因素.
- 步行速度每秒0.1米的增加与所有原因死亡率的显著降低有关 (HR:0.77).
- 尾肌瘦质量 (ALM) 和短物理性能电池 (SPPB) 评分也被确定为显著的预后因素.
结论:
- 患有HF和低ALM,低psoas肌肉质量,低SPPB或缓慢步行速度的患者面临全因死亡的风险增加.
- 准和治疗HF患者下肢身体功能下降可能是预防过早死亡的关键策略.
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