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Updated: Jul 8, 2025

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
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SHP2临床表型,癌症,或RASopathies,可以通过突变的构造性倾向来预测

Yonglan Liu1, Wengang Zhang1, Hyunbum Jang2

  • 1Cancer Innovation Laboratory, National Cancer Institute, Frederick, MD, 21702, USA.

Cellular and molecular life sciences : CMLS
|December 12, 2023
PubMed
概括

在SHP2酸酶的突变可以导致癌症或神经发育障碍 (NDD). 这项研究揭示了SHP2突变如何导致不同的结果,提供了结构性见解和潜在的药物战略.

关键词:
艾洛斯泰里克药物是一种药物.比托普抑制剂比托普抑制剂神经发育障碍 神经发育障碍在PTPN11中,酸酶是一种酸酶.在 Ras/MAPK 路径上.信号传输 信号传输

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