环境化物暴露和对儿童脏健康潜在风险的影响:采用尿路生物标志物的方法
T D K S C Gunasekara1, P Mangala C S De Silva2, E P S Chandana3
1Department of Zoology, Faculty of Science, University of Ruhuna, Matara, 81000, Sri Lanka.
Pediatric nephrology (Berlin, Germany)
|December 12, 2023
概括
斯里兰卡儿童的高化物暴露,特别是在干旱地区,并没有显示出与损伤生物标志物的强烈联系. 需要进一步的研究来了解环境化物对儿科脏健康的影响.
科学领域:
- 环境健康 环境健康
- 儿科脏病学 儿科脏病学
- 毒理学 毒理学 毒理学
背景情况:
- 环境中的高化物暴露是损伤和不确定病因的慢性病 (CKDu) 的潜在危险因素.
- 了解早期化物暴露对脏健康的影响至关重要,特别是在CKDu流行地区.
研究的目的:
- 在斯里兰卡调查化物暴露与儿科脏健康之间的关联.
- 为了比较来自CKDu影响和不受影响的社区的儿童的损伤生物标志物,其化物暴露水平各不相同.
主要方法:
- 这项研究涉及斯里兰卡四个气候区的922名学校学生 (11-18岁),包括CKDu流行和非流行地区.
- 参与者被分为四个尿化物 (UF) 四分位数进行分析.
- 测量了损伤生物标志物,包括尿路KIM-1,NGAL和白蛋白-肌素比率 (ACR).
主要成果:
- 尿液中的化物含量在CKDu流行的干旱区地区显著更高.
- 在具有较高UF四分位数的子组中观察到尿中NGAL和ACR的升高,但白蛋白尿并不普遍.
- 尿KIM-1没有显著变化,线性回归表明UF和损伤生物标志物之间存在弱相关性.
结论:
- 化物暴露在斯里兰卡的CKDu流行干旱区社区中特别高.
- 该研究没有发现观察到的化物暴露水平和儿科损伤生物标志物之间的强烈关联.
- 需要进一步调查以澄清化物暴露与儿童脏健康之间的关系.
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