从1990年到2019年,全球白血病负担是由于职业接触甲造成的
Ying Xu1, Yuqi Liu1, Hongyu Sun1
1Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China.
Environmental science and pollution research international
|December 12, 2023
概括
在1990-2019年间,职业形式甲暴露显著增加了全球白血病负担,特别是YLDs. 尽管死亡率下降,但残疾率上升和归因部分突出显示甲.
科学领域:
- 环境健康 环境健康
- 职业医学 职业医学是专业的.
- 流行病学 流行病学
背景情况:
- 甲是一种已知的人类致癌物,与白血病有关.
- 职业接触甲 (OEF) 是一个重大的公共卫生问题.
- 了解OEF导致的白血病的全球负担对于有针对性的干预至关重要.
研究的目的:
- 评估从1990年到2019年的职业甲暴露导致的白血病的全球负担.
- 根据地区,年龄,性别和疾病亚型分析白血病负担的趋势.
- 评估OEF对白血病发病率和死亡率的风险和影响.
主要方法:
- 利用了2019年全球疾病负担研究 (GBD) 的数据.
- 分析了因OEF而导致的白血病相关的死亡,YLL,YLD和DALY.
- 员工年平均百分比变化 (AAPC) 用于趋势分析和人口归因分数 (PAF) 用于风险评估.
主要成果:
- 来自OEF的白血病负担增加了:死亡率增加了44%,DALY增加了34%,YLL增加了33%,YLD增加了124% (1990-2019).
- 年龄标准化的YLDs率增加 (38.03%),而死亡率,DALY和YLL率下降.
- 在死亡,DALY,YLL和YLD的PAF中观察到增加的趋势,在中高中SDI地区的度更高.
- 急性白血病亚型显示OEF带来的更严重风险.
结论:
- 职业甲暴露引起的白血病仍然是一个重要的全球公共卫生问题.
- 虽然死亡率有所下降,但随着残疾人负担的增加,迫切需要制定政策.
- 有针对性的政策对于减轻OEF对白血病的影响至关重要,特别是在高风险地区和急性白血病亚型.
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