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用低剂量计算机断层扫描进行机会性查,以及中国肺癌死亡率

Lijie Wang^1,2,3, Yue Qi⁴, Ailing Liu⁵

¹Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.

JAMA network open

|December 12, 2023

概括

机会性低剂量计算机断层扫描 (LDCT) 查肺癌显著降低了成年人肺癌死亡率和全因死亡率. 这种查方法是基于人口的查计划的宝贵补充.

科学领域:

在瘤学瘤学.
公共卫生公共卫生
放射学放射学是一门学科.

背景情况:

肺癌查指南已经存在,但参与率,特别是在高风险人群中,仍然很低.
关于机会性低剂量计算机断层扫描 (LDCT) 查在降低肺癌死亡率方面的有效性,临床数据有限.

研究的目的:

评估机会性LDCT查与在中国诊断为肺癌的成年人中改善的预后之间的关联.

主要方法:

一项队列研究包括了5234名在2016-2021年期间被诊断为肺癌的肺癌患者.
倾向分数匹配 (PSM) 用于平衡群体,然后进行考克斯回归分析.
评估的结果是肺癌特异性和全因死亡率.

主要成果:

在PSM之后,分析了2788名患者 (1394人接受查,1394人没有接受查).
机会性LDCT查与49%的肺癌死亡风险降低有关 (HR,0.51).
观察到所有原因死亡风险降低了46% (HR,0.54).

结论:

使用LDCT进行机会性肺癌查与减少肺癌和全因死亡率有关.
这些发现凸显了机会性查作为改善肺癌患者结果的基于人口的查的关键补充.

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Computed Tomography

Computed Tomography

Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...