可修改的风险因素与阻塞性睡眠呼吸暂停的关联:孟德尔的随机化研究
Ye Li1,2, Yuyang Miao1,2, Jin Tan1,2
1Department of Geriatrics, Tianjin Medical University General Hospital, Tianjin 300052, China.
Aging
|December 12, 2023
概括
基因预测的健康状况不佳,白天小睡,高BMI和高血压会增加阻塞性睡眠呼吸暂停 (OSA) 的风险. 相反,高等教育水平减少了OSA风险,突出了预防的关键目标.
科学领域:
- 遗传学 是一个遗传学.
- 流行病学 流行病学
- 睡眠医学 睡眠医学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 的危险因素仍然不完全理解.
- 调查基因预测可修改的风险因素和生活方式行为对于识别OSA决定因素至关重要.
研究的目的:
- 系统地调查与阻塞性睡眠呼吸暂停 (OSA) 相关的基因预测可修改的风险因素和生活方式行为.
- 通过因果关联分析,确定OSA预防策略的关键目标.
主要方法:
- 采用双样本的门德尔随机化 (MR) 研究来评估34个风险因素与OSA之间的关联.
- 风险因素的遗传变异来源于欧洲血统的全基因组关联研究.
- 从FinnGen研究中获得了OSA数据,包括16,761例和201,194例对照,以反变量加权方法作为主要分析.
主要成果:
- 基因预测的整体健康评级不佳,白天小睡,高体重指数 (BMI),增加体脂量,增加体水量和高血压与明显更高的OSA风险有关.
- 高学历水平与OSA风险降低有关.
- 有关证据表明,吸烟和腰部与部比率 (WHR) 与OSA风险增加有关,强烈的体力活动和高密度胆固醇与OSA风险降低有关,但在调整BMI后,这些因素减弱了.
结论:
- 整体健康评级,白天小睡,BMI,体脂量,体水量,高血压和教育都与OSA风险有因果关系.
- 这些已识别的可修改因素代表了制定有效的OSA预防策略的关键目标.
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