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基于光声谱的呼吸分析用于SIBO

Xuefeng Mao¹, Yuting Tan¹, Hao Ye¹

¹Chongqing University of Posts and Telecommunications, No. 2 Chongwen Road, Chongqing 400065, China.

|December 12, 2023

概括

呼吸气和甲监测有助于胃肠道疾病的诊断. 一种新的光声谱学方法使用二氧化碳共振来准确检测气,满足临床需求.

科学领域:

胃肠道学和医学诊断
分析化学和光谱学.
生物医学工程生物医学工程

背景情况:

呼吸气体分析,特别是 (H2) 和甲 (CH4),对于诊断胃肠道疾病至关重要,如乳糖不耐症和小肠细菌过度生长 (SIBO).
目前的诊断方法可能需要提高灵敏度和特异性,以获得准确的临床应用.
光声谱学 (PAS) 提供了一种敏感的气体检测技术.

研究的目的:

开发和验证一种新的光声谱学 (PAS) 方法,用于同时检测呼吸中的H2和CH4.
建立一种新的方法来测量H2度,利用呼吸二氧化碳 (CO2) 反响频率和响应PAS细胞内的H2水平之间的线性关系.
使用开发的PAS系统评估H2,CH4和CO2的最小可检测限值 (MDL),以确保临床诊断实用性.

主要方法:

使用共振光声谱学 (PAS) 系统进行气体检测.
开发了一种用于测量H2度的新方法,该方法基于CO2响应H2存在的共振频率转移.
通过实验确定了H2,CH4和CO2的最小可检测极限 (MDL).

主要成果:

已达到H2的8.86 ppm,CH4的0.56 ppm和CO2的145.14 ppm的最小可检测限值 (MDL).
证明了CO2和H2度的共振频率之间的线性关系,使H2的精确测量成为可能.
获得的MDL符合临床呼吸诊断的灵敏度要求.

结论:

这种基于PAS的新方法为呼吸H2和CH4分析提供了灵敏而准确的方法.
该技术通过二氧化碳共振频率测量H2的能力提供了一个独特的,可能更强大的诊断工具.
这种方法显着有望通过非侵入性呼吸测试改善各种胃肠道疾病的诊断.

关键词:

这就是SIBO.呼出的气息呼出的气息多种多种的检测检测.光声谱学光谱学响应频率跟踪的共振频率跟踪

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