超大分子高血糖状态的发生率和特征:丹麦队列研究
Emilie V Rosager1, Amalia Lærke K Heltø1, Cathrine U Fox Maule2
1Department of Emergency Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.
在1型糖尿病患者中,高血糖水平 (hyperosmolar hyperglycemic state,HHS) 的发生率高于2型糖尿病患者. HHS可以呈现为一个频谱,其中三分之一的病例是糖尿病的第一个迹象.
科学领域:
- 内分泌学和新陈代谢学
- 糖尿病并发症 糖尿病并发症
- 公共卫生流行病学 流行病学
背景情况:
- 超大胞高血糖状态 (HHS) 是一种严重的,危及生命的糖尿病并发症.
- 了解HHS发病率和患者个人资料对于临床管理至关重要.
- 重要的是对HHS的亚组分析,其中包括酸性疾病和急性损伤.
研究的目的:
- 为了估计丹麦HHS的发病率.
- 描述HHS患者的临床和生物标志物概况.
- 分析HHS的子组,包括患有酸性结核和急性损伤的人.
主要方法:
- 全国范围的描述性队列研究,使用丹麦注册数据 (2016-2018).
- 确定符合HHS标准 (葡萄糖≥33 mmol/L,度≥320 mmol/L) 的急性入院患者.
- 分析了480万年龄≥18岁居民的数据.
主要成果:
- 确定了634名HHS患者;发生率为1型糖尿病的16.5/10,000人/年,为2型糖尿病的3.9/10,000人/年.
- 32%的HHS患者之前没有被诊断为糖尿病.
- 住院死亡率为17%纯HHS和9%的HHS与糖尿病酸性脂肪酸 (HHS-DKA).
结论:
- 与2型糖尿病相比,HHS发生率在1型糖尿病中明显高于2型糖尿病.
- HHS代表了一系列的高血糖危机,包括纯HHS和HHS-DKA.
- 在HHS病例中,很大一部分 (32%) 是糖尿病的初始诊断.
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