在脑炎中临床结果评估:系统性审查
Juliette Brenner1, Sammy H C Olijslagers1, Yvette S Crijnen1
1From the Department of Neurology (J.B., Y.S.C., J.M.V., M.R.M., M.J.T.), Erasmus University Medical Center, Rotterdam; and Department of Neurology (S.H.C.O.), Canisius Wilhelmina Hospital, Nijmegen, the Netherlands.
Neurology(R) neuroimmunology & neuroinflammation
|December 12, 2023
概括
对于脑炎,没有经过验证的患者报告结果测量方法 (PROMs),这阻碍了对长期神经认知和神经精神影响的准确评估. 开发特定的PROM对于改善患者护理和对脑炎结果的研究至关重要.
科学领域:
- 神经学 神经学
- 临床研究方法论 临床研究方法论
- 患者报告的结果
背景情况:
- 大脑炎经常导致持续的神经认知和神经精神疾病的后果.
- 目前的结果评估往往缺乏患者的观点,可能低估了疾病特异性的影响.
- 缺乏针对脑炎的经过验证的患者报告结果指标 (PROMs).
研究的目的:
- 系统地审查在脑炎患者中开发或验证的PROM的文献.
- 确定现有的工具,可能评估脑炎患者的结果.
主要方法:
- 对2023年5月之前发表的研究进行系统文献综述.
- 在MEDLINE,EMBASE和Cochrane图书馆搜索了在脑炎或脑病变中开发或验证PROM的研究.
- 使用基于共识的健康状况测量仪器选择标准 (COSMIN) 清单评估方法质量.
主要成果:
- 没有特定疾病的PROM被确定为针对脑炎的开发或验证.
- 发现了一种肝脏脑病变的PROM,但其疾病过程有显著差异.
- 在脑炎研究中应用了30个PROM,但未为该人群验证,常用的工具包括SF-36,SIP和BDI-II.
结论:
- 对脑炎患者的验证结果评估工具存在关键差距.
- 开发和验证特定疾病的PROM对于准确的患者管理和临床试验至关重要.
- 这种措施是必要的,以捕捉被忽视的神经认知,功能和健康状况的影响在脑炎幸存者.
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