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用于神经母细胞瘤治疗的基于碳水化合物的阿普雷皮坦类 analog 的生物评估

Victoria Valdivia1, Rocío Recio1, Patricia Lerena1

  • 1Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad de Sevilla, C/ Profesor García González, 2, 41012, Sevilla, Spain.

European journal of medicinal chemistry
|December 12, 2023
PubMed
概括

新的基于碳水化合物的阿普雷匹坦类型显示出强大和选择性的抗神经母细胞瘤 (NB) 活性. 衍生品2α表现出强烈的细胞毒性作用,而衍生品10α与阿普雷皮坦相比,表现出更高的选择性和活性.

关键词:
这是一种阿普雷皮坦特 (Aprepitant).基于碳水化合物的衍生品.NK1R 的抗体.神经母细胞瘤是一种神经母细胞瘤.

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