使用大麻的50岁以上成年人中的精神和物质使用障碍:使用电子健康记录数据进行的一项匹配队列研究
Kristina T Phillips1, Kathryn L Pedula2, Vanessa Simiola3
1Center for Integrated Health Care Research, Kaiser Permanente Hawai'i, Honolulu, HI; Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, CA.
Addictive behaviors
|December 12, 2023
概括
使用大麻的老年人面临着随后精神病和物质使用障碍 (SUD) 的更高风险. 这项研究强调了50岁以上的个人对大麻的潜在健康风险.
科学领域:
- 老年学是一门学科.
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 在50岁以上的成年人中增加大麻使用需要了解同时发生的精神病和物质使用障碍 (SUD).
- 在老年人群中,大麻使用对长期心理健康和SUD影响的研究有限.
研究的目的:
- 为了比较老年人中精神病和SUD的发病率,有和没有大麻使用代码.
- 调查大麻使用与50岁及以上成年人随后诊断的抑郁,焦虑和其他SUD之间的关联.
主要方法:
- 一个匹配的队列研究设计,使用来自夏威夷 (2016-2020) 综合医疗保健系统的电子健康记录 (EHR) 数据.
- 确定了275个ICD-10大麻代码的病例和275个匹配的对照 (年龄,性别) 没有大麻代码.
- 在两年的随访期间,对重大抑郁症,焦虑症和特定SUD (烟草,阿片类药物,酒精) 的诊断进行了病例和对照.
主要成果:
- 50岁以上的成年人使用大麻代码显示严重抑郁症 (OR=10.68) 和任何焦虑症 (OR=6.45) 的几率明显更高.
- 对于特定的焦虑障碍 (例如,GAD,PTSD) 和SUD,也观察到更高的几率,几率比率从2.72到16.00不等.
- 在夏威夷的多样化人口中,研究结果一致.
结论:
- 在两年的时间里,使用大麻的老年人经历了明显更高的随后精神病和SUD的比率.
- 这些结果强调了向老年人提供有关大麻潜在健康风险的信息的重要性.
- 需要进一步的研究来探索因果机制,并为这一群体提供临床指导方针.
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