血清维生素D与绝经后妇女死亡率的相关性
Jinmin Liu1, Cong Tian1, Yuchen Tang1
1Department of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China; Orthopaedics Key Laboratory of Gansu Province, Lanzhou, Gansu, China; Orthopaedic Clinical Research Center of Gansu Province, Lanzhou, Gansu, China.
Clinical nutrition (Edinburgh, Scotland)
|December 12, 2023
概括
较高的血清维生素D水平显著降低了绝经后妇女的死亡风险. 维护足够的维生素D可能有助于预防所有原因,心血管疾病和癌症的过早死亡.
科学领域:
- 内分泌学 在内分泌学.
- 老年学是一门学科.
- 营养科学 营养科学
背景情况:
- 证据表明血清维生素D与绝经后妇女的死亡率有关,这些证据有限且不一致.
- 维生素D在各种生理过程中起着至关重要的作用,包括骨健康和免疫功能.
研究的目的:
- 调查血清维生素D度与绝经后妇女的死亡风险之间的关联.
- 确定维生素D水平是否与全因,心血管疾病 (CVD) 和癌症死亡率相关.
主要方法:
- 利用了2001-2018年国家健康和营养检查调查 (NHANES) 的数据.
- 采用多变量考克斯回归模型来分析血清维生素D与死亡结果之间的关系.
- 随访参与者的平均时间为8.3年,记录了死亡原因.
主要成果:
- 较高的血清维生素D水平与所有原因死亡率 (HR 0.60),心血管疾病死亡率 (HR 0.51) 和癌症死亡率 (HR 0.43) 的降低风险显著相关.
- 维生素D水平较高 (≥75.0nmol/L) 的参与者与水平较低 (<25nmol/L) 的参与者相比,风险明显较低.
- 在维生素D水平和全因和癌症死亡率之间观察到L形的剂量反应关系,折叠点分别为55.9nmol/L和51.2nmol/L.
结论:
- 血清维生素D度升高与绝经后妇女因所有原因,心血管疾病和癌症死亡风险显著降低有关.
- 维持足够的维生素D水平可能是预防这一群体过早死亡的关键策略.
- 对绝经后妇女最佳维生素D补充策略的进一步研究是有必要的.
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