身体活动和萨尔科佩尼亚对发生性缺血性心脏病的相互作用影响:来自全国性队列研究的结果
Zhihan Lai1, Gan Wu1, Yin Yang1
1Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, China.
Atherosclerosis
|December 12, 2023
概括
低体力活动 (PA) 和皮症显著增加缺血性心脏病 (IHD) 的风险. 它们的组合显示出协同效应,突出显示了对IHD综合预防策略的需要.
科学领域:
- 心脏病学 心脏病学
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 身体不活动和肉类是已确定的缺血性心脏病 (IHD) 的危险因素.
- 身体不活动和肉毒症对心血管疾病风险的综合影响,特别是在中年和老年人中,需要进一步调查.
- 了解这种相互作用对于制定有针对性的预防策略至关重要.
研究的目的:
- 调查体力活动 (PA) 水平和肉症对发生性缺血性心脏病 (IHD) 的风险的相互作用影响.
- 分析低PA和肉症对IHD亚型的综合影响.
- 提供证据,以加强IHD的初级预防.
主要方法:
- 利用了来自344,688名英国生物库参与者的数据,不包括那些先前患有IHD的参与者.
- 使用国际体力活动问卷将PA分为低,中等和高,并根据既定的标准确定了基于萨科佩尼亚的标准.
- 采用了考克斯的比例危险模型,并用来自手腕设备的客观PA数据验证了这些发现.
主要成果:
- 在11.7年内,低血压与心脏病发作的风险增加有关,与没有 (HR1.09) 相比,在患有肉症的人群中观察到更高的风险 (HR1.29).
- 低血压和肉症的组合表明了协同作用,显著增加了IHD风险 (HR 1.54,RERI 0.27,p-相互作用<0.01).
- 这种相互作用在急性心肌梗塞和慢性缺血性心脏病亚型中尤为明显.
结论:
- 低体力活动和肉症之间存在协同作用,大大增加了缺血性心脏病的风险.
- 这些发现强调了同时解决身体不活动和肉症对于有效的IHD初级预防的重要性.
- 针对这两种因素的综合干预措施可能会在减少IHD发病率方面取得更好的结果.
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