截然不同的前额外投影活动和转录状态反过来指挥社会竞争和层次结构
Tae-Yong Choi1, Hyoungseok Jeon2, Sejin Jeong3
1Emotion, Cognition and Behavior Research Group, Korea Brain Research Institute, Daegu 41062, Republic of Korea.
Neuron
|December 12, 2023
概括
社会层次是由明显的中间前额叶皮层 (mPFC) 神经元路径形成的. 这项研究确定了特定的mPFC预测,控制了赢和输的行为,与Pou3f1基因表达相关,影响了社会地位.
科学领域:
- 神经科学是一个神经科学.
- 行为遗传学 行为遗传学
- 社会行为 社交行为
背景情况:
- 社会层次结构源于对资源的竞争.
- 中间前额叶皮层 (mPFC) 对于社会主导至关重要.
- 参与社会竞争的mPFC中特定的神经元子群仍然未被确定.
研究的目的:
- 在编码社会竞争行为的mPFC中识别不同的神经元子群.
- 阐明社会层次结构的分子基础.
- 调查特定的mPFC预测在社会主导地位中的作用.
主要方法:
- 高通量单细胞转录组分析.
- 对mPFC神经元的投影特异性基因操纵.
- 对mPFC-VTA神经元活动的光遗传学操纵.
主要成果:
- 投射到核的mPFC神经元 (mPFC-NAc) 编码获胜的行为.
- 投射到腹膜区域 (mPFC-VTA) 的mPFC神经元编码失败行为.
- 在mPFC-VTA神经元中的Pou3f1表达调节了社会层次;增加表达降低了社会等级.
结论:
- 离散的mPFC预测差异调节了社会赢和输的行为.
- 在mPFC-VTA神经元中的Pou3f1表达是社会地位的关键分子决定因素.
- 在不同的mPFC路径中,相反的神经活动和基因表达模式协调社会竞争和层次结构.
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