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对立的杏仁体组合的全息刺激通过相互抑制双向调节值特异性行为
Sean C Piantadosi1, Zhe Charles Zhou1, Carina Pizzano1
1Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA; Center for the Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA, USA.
Neuron
|December 12, 2023
概括
研究人员发现,特定群体的底侧杏仁体 (BLA) 神经元控制价值特异性行为. 激活这些神经元组合直接影响小鼠是否接近或避免食欲或厌恶的刺激.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
背景情况:
- 底侧杏仁体 (BLA) 对于处理刺激的价值 (食欲与厌恶) 是至关重要的.
- BLA神经元组合活动与价值特异性行为之间的确切因果关系尚不清楚.
研究的目的:
- 研究对抗BLA神经元组合在控制价值特异性行为中的直接因果作用.
- 了解BLA活动如何与食欲和厌恶行为的表达有关.
主要方法:
- 利用双光子成像来监测BLA神经元活动.
- 通过内镜透镜使用单细胞全息光刺激来向神经元激活.
- 评估了在BLA组合操纵后对食欲和厌恶刺激的行为反应.
主要成果:
- 针对食欲或厌恶性BLA组合的有针对性的光刺激导致了相互抑制.
- 激活特定的BLA合奏改变了行为,促进消费厌恶品味或减少食欲的消费.
- 在BLA中,神经元对价值的编码是分级的,这取决于特定组合中招募的神经元的比例.
结论:
- 证明了对抗BLA神经元组合在控制相反的价值行为方面具有直接的因果作用.
- 确定BLA神经元活动模式直接影响食欲和厌恶刺激之间的行为选择.
- 根据集体招募,在BLA内确定了一种对价值的分级神经元编码机制.
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