在牛津-阿斯特拉泽内卡COVID-19疫苗接种后,ABO血型与脑静脉血栓相关:一个病例控制研究
Gie Ken-Dror1, Pankaj Sharma1,2,
1Institute of Cardiovascular Research Royal Holloway, University of London (ICR2UL), London TW20 0EX, UK.
Journal of the Royal Society of Medicine
|December 12, 2023
概括
血型为O的个体在接种AstraZeneca的COVID-19疫苗后,患有疫苗诱导的血栓性血栓性缺血症 (VITT-CVT) 的风险更高. 这一发现表明,血型可能会影响脑静脉血栓症 (CVT) 疫苗的安全性.
科学领域:
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 大脑静脉血栓形成 (CVT) 是一种罕见但严重的疾病.
- 阿斯特拉泽内卡ChAdOx1-S疫苗已与疫苗诱导的血栓性血栓性缩症 (VITT) 有关.
- 血型在VITT-CVT发展中的作用需要进一步研究.
研究的目的:
- 调查AstraZenecaCOVID-19疫苗接种后ABO血型与发展CVT风险之间的关联.
- 为了确定血型是否是VITT-CVT的独立风险因素.
主要方法:
- 进行了一项病例控制研究.
- 后勤回归分析用于比较疫苗接种和未接种CVT患者之间的血型频率.
- 患者根据年龄和性别进行了匹配.
主要成果:
- 与未接种疫苗的对照组相比,在ChAdOx1-S疫苗接种后发生VITT-CVT的患者中,血型O显著更为普遍 (43%对17%).
- 与未接种疫苗的对照组相比,接种疫苗的血液组A的流行率较低 (47%vs71%).
- 在非ChAdOx1-S疫苗VITT-CVT或COVID-19前CVT组中没有发现显著的血型差异.
结论:
- 血型O与ChAdOx1-S疫苗接种后VITT-CVT的风险增加有关,独立于其他风险因素.
- 需要对更大的数据集进行进一步的研究,以评估B和AB血型个体ChAdOx1-S疫苗接种的安全性.
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