通过正统相关性分析进行数据整合,并将其应用于OMIC研究
Sonia Wróbel1, Cezary Turek2, Ewa Stępień3
1Department of Medical Physics, Jagiellonian University, Marian Smoluchowski Institute of Physics, Krakow, Poland.
Journal of biomedical informatics
|December 12, 2023
概括
规范性相关性分析 (CCA) 提供了一种强大的多维方法,用于奥米克数据研究. 这次审查强调了CCA的重点.
科学领域:
- 生物信息学是一种生物信息学.
- 计算生物学 计算生物学
- 生物统计学 生物统计学
背景情况:
- 高吞吐率的方法产生了大量的欧米克数据,需要先进的分析技术.
- 了解复杂的生物过程需要整合来自多个组织层面的数据.
- 多维分析提供了对生物现象的更现实的评估.
研究的目的:
- 审查多维数据分析方法,重点关注正统相关性分析 (CCA) 和其变体.
- 强调CCA在欧米克数据研究中的应用.
- 探索CCA在发现新生物学见解方面的潜力.
主要方法:
- 对多维数据分析现有文献的审查.
- 专注于正统相关性分析 (CCA) 和它的各种实现.
- 将CCA应用于用于生物过程分析的omics数据集.
主要成果:
- 通过CCA,可以同时分析多组生物分子数据.
- CCA简化了复杂的多维视图,以便在实践中解释.
- CCA促进了相互依赖的研究,例如瘤微环境中的细胞间通信.
结论:
- 规范性相关性分析是奥米克数据研究的重要工具.
- CCA为探索复杂的生物系统提供了独特的方法.
- 进一步探索CCA在生物医学科学中的潜力是有必要的.
相关概念视频
Correlation of Experimental Data
232
Dimensional analysis simplifies complex physical problems and guides experimental investigations, but it does not provide complete solutions. It identifies the dimensionless groups that influence a phenomenon, but experimental data is needed to establish the specific relationships and validate theoretical predictions.
For example, a spherical particle moving through a viscous fluid experiences drag. Dimensional analysis shows that the drag force depends on the particle's diameter, velocity,...
For example, a spherical particle moving through a viscous fluid experiences drag. Dimensional analysis shows that the drag force depends on the particle's diameter, velocity,...
232
Correlation and Regression
1.3K
In statistics, correlation describes the degree of association between two variables. In the subfield of linear regression, correlation is mathematically expressed by the correlation coefficient, which describes the strength and direction of the relationship between two variables. The coefficient is symbolically represented by 'r' and ranges from -1 to +1. A positive value indicates a positive correlation where the two variables move in the same direction. A negative value suggests a...
1.3K
Calculating and Interpreting the Linear Correlation Coefficient
6.0K
The correlation coefficient, r, developed by Karl Pearson in the early 1900s, is numerical and provides a measure of strength and direction of the linear association between the independent variable, x, and the dependent variable, y. Hence, it is also known as the Pearson product-moment correlation coefficient. It can be calculated using the following equation:
6.0K
Coefficient of Correlation
6.2K
The correlation coefficient, r, developed by Karl Pearson in the early 1900s, is numerical and provides a measure of strength and direction of the linear association between the independent variable x and the dependent variable y.
If you suspect a linear relationship between x and y, then r can measure how strong the linear relationship is.
What the VALUE of r tells us:
The value of r is always between –1 and +1: –1 ≤ r ≤ 1.
The size of the correlation r indicates the...
If you suspect a linear relationship between x and y, then r can measure how strong the linear relationship is.
What the VALUE of r tells us:
The value of r is always between –1 and +1: –1 ≤ r ≤ 1.
The size of the correlation r indicates the...
6.2K
Correlations
32.8K
Correlation means that there is a relationship between two or more variables (such as ice cream consumption and crime), but this relationship does not necessarily imply cause and effect. When two variables are correlated, it simply means that as one variable changes, so does the other. We can measure correlation by calculating a statistic known as a correlation coefficient. A correlation coefficient is a number from -1 to +1 that indicates the strength and direction of the relationship between...
32.8K
Correlation
11.8K
In statistics, two variables are said to be correlated if the values of one variable are associated with the other variable. Depending on the relationship between two variables, correlation can be of three types– positive correlation, negative correlation, and zero correlation.
Two variables, for example, a and b, are said to be positively correlated if both variables move in the same direction. In other words, a positive correlation exists between two variables, a and b, if:
Two variables, for example, a and b, are said to be positively correlated if both variables move in the same direction. In other words, a positive correlation exists between two variables, a and b, if:
11.8K


