刷式聚乙烯甘醇聚合物与特定脂质的功能化通过与天然脂质贩运途径的结合,延长了它们的消除半衰期

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Mohammad Abdallah1, Lihuan Lin1, Ian K Styles1

  • 1Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.

Acta biomaterialia
|December 12, 2023
PubMed
概括

将刷毛聚乙烯甘醇 (PEG) 聚合物与脂质相结合会改变它们的药理动力学特性. 脂质结合,特别是与dialkyl脂质和胆固醇,增强与脂质通路的关联,延长治疗半衰期以改善药物输送.

关键词:
专辑中的专辑蛋白.刷毛聚乙烯糖醇的使用方法脂蛋白质是一种脂蛋白质.血的半衰期 血的半衰期聚合物前药物 聚合物前药物

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