相关实验视频

Updated: Jul 8, 2025

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy

Published on: October 4, 2019

在质母细胞瘤中的外体长非编码RNA

Mehdi Fattahi¹, Vahab Alamdari-Palangi², Khojaste Rahimi Jaberi³

¹Institute of Research and Development, Duy Tan University, Da Nang, Viet Nam; School of Engineering & Technology, Duy Tan University, Da Nang, Viet Nam.

Clinica chimica acta; international journal of clinical chemistry

|December 12, 2023

概括

多形质母细胞瘤 (GBM) 的诊断需要改进. 外体长非编码RNAs (lncRNAs) 显示为早期GBM检测和预后的敏感生物标志物具有前途.

科学领域:

神经瘤学神经瘤学
分子生物学分子生物学
生物标志物发现发现

背景情况:

多形质母细胞瘤 (GBM) 是成年人中最常见和最具攻击性的原发性脑瘤.
目前的诊断方法 (MRI,活检) 在准确性和侵入性方面存在局限性.
对于GBM来说,急需具有最小入侵性,准确且具有成本效益的诊断工具.

研究的目的:

审查外体长非编码RNAs (lncRNAs) 在GBM病变发生中的作用.
探索外体lncRNAs作为早期GBM诊断和预后的生物标志物的潜力.
讨论外体lncRNAs在GBM管理中的临床应用.

主要方法:

文献综述侧重于GBM中的外体lncRNAs.
对研究的分析,研究 lncRNAs 在 GBM 发育和进展中的调节作用.
对外体lncRNA特异性和对诊断潜力的敏感性研究的评估.

主要成果:

外体lncRNAs与GBM免疫调节,转移,发育和耐药性有关.
这些ncRNAs调节促进瘤生长和改变信号通路的基因.
外体lncRNAs具有很高的特异性和敏感性,使其成为有前途的诊断指标.

结论:

外体lncRNAs是GBM病变发生的关键参与者.
这些分子作为早期GBM诊断的非侵入性生物标志物具有显著的潜力.
进一步的研究可以将外体lncRNA检测转化为临床应用,以改善患者的治疗结果.

关键词:

生物标志物生物标志物诊断诊断诊断诊断诊断这是外体外的.在GBMGBMGBMGBMGBM 治疗方法治疗方法在 lncRNAs 中.

更多相关视频

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Published on: July 31, 2017

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

相关概念视频

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

Non-LTR Retrotransposons

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...