在一次性甲状腺功能障碍症中发生胆结石疾病的风险:系统性审查和元分析
Rimesh Pal1, Mainak Banerjee2, Trupti N Prasad1
1Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
概括
胆结石病 (GSD) 在患有原发性副甲状腺症 (PHPT) 的患者中更为常见. 这表明PHPT是发展胆结石的额外危险因素.
科学领域:
- 内分泌学和新陈代谢学
- 胃肠病学和肝病学 胃肠学和肝病学
背景情况:
- 原发性偏甲状腺症 (PHPT) 与各种并发症有关,包括结石和潜在的胆结石疾病 (GSD).
- 之前关于PHPT和GSD之间的联系的研究已经产生了不一致的结果,需要进行全面的分析.
研究的目的:
- 系统地审查和对GSD和PHPT之间关联的现有证据进行元分析.
- 提供与对照组相比,PHPT患者中GSD患病率和PHPT中GSD风险的综合估计.
主要方法:
- 在PubMed/MEDLINE,Embase和Web of Science数据库进行系统搜索,截至2023年5月10日.
- 包括7项观察性研究,其中包括15949名PHPT患者的数据.
- 使用随机效应模型计算PHPT患者与对照群的GSD综合患病率和GSD的几率比率 (OR).
主要成果:
- 在PHPT患者中,GSD的综合流行率为16% (95%CI:7%,25%).
- 在印第安人中,患病率为13%,在高加索人中为17%.
- 与对照组相比,PHPT患者中GSD的合并OR为1.77 (95%CI:1.60,1.97,P <.001).与对照组相比,PHPT患者中的GSD的合并OR为1.77 (95%CI:1.60,1.97,P <.001).
结论:
- 胆结石病在患有原发性副甲状腺功能障碍的人群中明显更为普遍.
- 初级甲状腺功能障碍症应该被认为是导致胆结石疾病的危险因素.
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