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Updated: Jul 8, 2025

Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors
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只有瘤的综合基因组分析中检测到具有低变异基因频率的生殖系BRCA2变异

Hideyuki Hayashi1, Kei Kunimasa2, Shigeki Tanishima3

  • 1Genomics Unit, Keio Cancer Center, Keio University School of Medicine, Tokyo, Japan.

Cancer science
|December 12, 2023
PubMed
概括

生殖系BRCA1/2变种可以在瘤单独综合基因组分析 (CGP) 中呈现低变异基因频率 (VAF),这是由于基因损失. 这一发现表明,即使在BRCA1/2突变中VAF低,也应该考虑生殖系起源.

关键词:
这就是BRCA BRCA.这是一种PARP抑制剂.基因组损失 基因组损失在低VAF的VAF中.只有瘤的CGP.

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