(-) - 甲基因对肝脏甘油三代谢的作用
Zahra Mostofinejad1, Eleonora Cremonini1, Jiye Kang1
1Department of Nutrition, University of California, One Shields Avenue, Davis, CA 95616, USA. poteiza@ucdavis.edu.
Food & function
|December 12, 2023
概括
在小鼠中, (-) - 甲 (EC) 补充剂增加了肝脏甘油三合成和脂肪酸氧化,表明其对肝脏健康的安全性. 这表明EC可能有助于管理与肥胖相关的代谢变化.
科学领域:
- 生物化学 生物化学
- 代谢健康 代谢健康
- 营养保健品 营养保健品
背景情况:
- (-) - 甲 (EC) 消费与改善的高脂血症和代谢功能障碍有关.
- 肥胖和西方饮食有助于不利的代谢变化.
- 了解EC对甘油三 (TG) 代谢的影响对于其治疗潜力至关重要.
研究的目的:
- 调查EC对活体和体外甘油三代谢的影响.
- 评估关于肝脏结构和功能的EC安全性.
- 阐明EC对TG合成和脂肪酸氧化影响的分子机制.
主要方法:
- 在体内研究:小鼠补充EC (2和20毫克/体重公斤) 持续24周.
- 在体外研究:人类HepG2肝细胞与EC及其血代谢产物进行化.
- 分析肝脏TG水平,肝脏结构,炎症,氧化应激,DGAT2表达和PPARα活性.
主要成果:
- 在小鼠中长期服用EC补充剂 (20 mg/kg) 增加了肝脏TG水平,但保留了肝脏结构,没有炎症或氧化应激.
- 在小鼠肝脏中,EC上调的二甲基甘油酸转移酶2 (DGAT2) 和过氧体增殖器激活受体α (PPARα).
- 在体外,高EC度没有影响HepG2细胞中的TG沉积或DGAT2表达.
结论:
- 在小鼠肝脏中,EC可对TG合成和脂肪酸氧化进行上调,从而可能中和脂肪酸的毒性.
- 结果表明,EC对TG代谢是安全的,并且在适用于人类消费的剂量下不会诱导肝病.
- 在代谢调节的背景下,EC证明了肝脏健康的良好的安全性.
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