在产前症中内皮氧化合成酶基因变异的关联:更新的系统性审查和元分析
Endalamaw Tesfa1,2, Abaineh Munshea2,3, Endalkachew Nibret2,3
1Department of Biochemistry, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.
概括
在894和786位置的某些内皮氧化合成酶 (eNOS) 基因变异与更高的孕前 (PE) 风险有关. 然而,内突-4区域的eNOS基因变异与PE风险没有显著的关联.
科学领域:
- 遗传学 是一个遗传学.
- 心血管生物学 心血管生物学
- 生殖医学 生殖医学
背景情况:
- 孕前 (PE) 是一种具有复杂病因的妊娠严重并发症.
- 内皮氧化合成酶 (eNOS) 基因变异,特别是G-894T,T-786C和VNTR内4基因变异,已与PE风险有关,但研究结果仍在争论中.
结论:
- 在894和786位置的eNOS基因变异与子宫前风险增加有显著的关联.
- 内部-4区域的eNOS基因变异与PE风险没有显著的关联.
- 虽然eNOS基因变异可能有助于PE发展,但需要进一步的大规模研究才能确定确的证据.
相关概念视频
01:28Nitric Oxide Signaling Pathway
5.0K
Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...
5.0K
01:18Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
170
Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
170