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在精密免疫疗法中利用生物工程的骨髓原体

Willem Buys¹, Elias T Zambidis²

¹Institute for Cell Engineering, and Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

NPJ Regenerative medicine

|December 12, 2023

概括

工程化髓状细胞为感染和癌症提供了新的细胞治疗潜力. 研究人员正在探索诱导多能干细胞和造血干细胞,以克服这些重要免疫防御者的生产挑战.

科学领域:

免疫学免疫学免疫学
细胞疗法细胞疗法
生物技术是生物技术.

背景情况:

粒细胞和巨细胞是关键的先天性免疫细胞,对于病原体清除和免疫调节至关重要.
这些髓状细胞的缺陷,在新生儿败血症和化疗后的亚核细胞瘤症中见到,增加感染易感性.
工程化髓状细胞提供了超出简单细胞替代的新疗法.

研究的目的:

审查使用工程化髓状细胞原始体的生物治疗创新.
解决这些细胞疗法的采购,成本和生产方面的挑战.
概述未来发展的路线图.

主要方法:

审查当前和未来的生物治疗创新.
专注于工程化多强的髓状细胞原始体.
从人类诱导的多能干细胞 (hiPSC) 或初级CD34+造血干细胞原始细胞衍生.

主要成果:

工程化髓状细胞可以用于针对性地提供治疗剂 (杀菌剂,抗炎药物).
用化学抗原受体 (CAR) 改造的髓状细胞的潜力,以增强瘤杀伤.
在局部治疗策略中利用中性粒细胞定位.

结论:

工程骨髓状细胞疗法在治疗感染,自身免疫性疾病和癌症方面具有重大前景.
克服细胞采购,成本和生产方面的局限性是临床翻译的关键.
利用hiPSC和CD34+原始体为产生这些先进的细胞疗法提供了可扩展的解决方案.

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