中国广东省第一个本地病毒集群的原生和分子进化
Jianhai Yu1, Xin Zhang2,3, Jiajun Liu2,3
1BSL-3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No. 1023, South Shatai Road, Baiyun District, Guangzhou, Guangdong Province, 510515, China.
Nature communications
|December 12, 2023
概括
2023年广东首次爆发的mopox疫情显示,当地有无声传染. 分子分析揭示了一种IIb C.1血统,具有持续的进化,与国际mopox病例有关.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 基因组学就是基因组学.
背景情况:
- 中国广东省最初的mopox疫情始于2023年6月.
- 由于流行病学数据有限,疫情的来源和传播途径的快速识别受到阻碍.
研究的目的:
- 描述来自广东疫情的mpox病毒 (MPXV) 基因组的细胞系和分子进化.
- 调查潜在的无声局部传播和分子流行病学与其他地区的联系.
主要方法:
- 来自广东的10个MPXV基因组序列的遗传学分析.
- 分子进化分析专注于单核酸多态 (SNPs) 和共享突变.
- 与来自日本的MPXV和其他血统进行比较基因组分析.
主要成果:
- 广东MPXV属于IIb C.1血统,表现出遗传特征的时间连续性和独特的突变频谱.
- 有证据表明,在广东省内有无声的局部传输.
- 与日本MPXV相比,观察到基因组差异,确定了14种共享突变,其中包括6种影响宿主相互作用和病毒生命周期的非同义突变.
- 编辑阿波利波蛋白B mRNA的催化型多类3基因与病毒进化和多样化有关.
结论:
- 该研究确定了广东mopox疫情与国际病例以及中国其他地区之间的分子流行病学联系.
- 血统IIb C.1的独特突变谱和时间连续性有助于病毒快速演变.
- 调查结果为了解中国的mopox疫情提供了洞察力,并为预防和控制策略提供了信息.
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