相关实验视频
Updated: Jul 8, 2025

08:36
Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3
Published on: April 7, 2023
1.1K
在日本患者中使用imaradenant (AZD4635) 的安全性和药理动力学:一期I期,开放标签研究
Nobuaki Matsubara1, Shota Kusuhara2, Noboru Yamamoto3
1Department of Medical Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan. nmatsuba@east.ncc.go.jp.
Cancer chemotherapy and pharmacology
|December 12, 2023
概括
一种腺A2A受体对抗剂Imaradenant在患有高级固体瘤的日本患者中显示出可接受的安全性. 需要进一步的研究来探索其在减少免疫抑制方面的抗瘤潜力.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 免疫学 免疫学 免疫学
背景情况:
- 伊马拉登是一种新型腺A2A受体对抗剂.
- 假设它可以减少瘤微环境中的免疫抑制.
- 氨酸A2A受体对抗剂正在研究用于癌症治疗.
研究的目的:
- 为了评估imaradenant的安全性,药理动力学和抗瘤活性.
- 评估在日本患者中具有晚期固体恶性瘤的imaradenant.
主要方法:
- 第一阶段,开放标签,剂量升级研究.
- 日本的患者每天接受一次50毫克或75毫克的伊玛拉登坦.
- 主要终点:安全性和耐受性;次要终点:药理动力学和抗瘤活性.
主要成果:
- 平均治疗持续时间约为2.1个月.
- 最常见的不良事件包括恶心,不适,食欲下降和吐.
- 报告没有严重的不良事件或死亡;50%的人经历了因果相关的不良事件.
- 药物动力学分析显示,在多次剂量后药物积累最小.
- 最好的客观反应是10名患者中3名患者的稳定疾病.
结论:
- 伊玛拉登安特在每天一次服用50毫克和75毫克时都显示出可接受的安全性.
- 没有发现新的或意想不到的安全问题.
- 这项研究为进一步调查癌症治疗中的伊玛拉登提供了基础.
更多相关视频
相关概念视频
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
167
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy. SP binds and activates...
167
Radiological Investigation III: Pulmonary Angiogram and PET Scan
95
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
95

