人类白质结构连接体的纵向发展及其与大脑转录和细胞架构的关联
Guozheng Feng1,2,3, Rui Chen1, Rui Zhao4,5
1State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.
Communications biology
|December 12, 2023
概括
这项研究揭示了人类大脑是如何工作的.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 遗传学 是一个遗传学.
背景情况:
- 人类大脑白质连接器从童年到青春期的时空发展还不清楚.
- 推动这种发展的潜在的转录组和细胞机制在很大程度上是未知的.
研究的目的:
- 绘制整个童年和青春期白质连接体的发育轨迹.
- 识别可能调节白质连接体发育的转录和细胞因素.
主要方法:
- 604名参与者的纵向扩散MRI数据.
- 全球和区域大脑网络属性的分析.
- 连接组-转录组相关性分析.
主要成果:
- 大多数大脑网络属性都表现出线性发育轨迹.
- 连接组-转录组分析表明通过转录组架构来调节基因.
- 髓含量和膜厚度与宏观发育模式相关联.
结论:
- 白质连接体的发展从童年到青春期基本上遵循线性轨迹.
- 转录组结构,涉及特定的基因通路和细胞类型,可能调节这种发展.
- 髓和皮质层厚度与宏观白质发育有关.
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